An experimental campaign of arrays with direct-driven wave energy converters of point-absorbing type is presented. The arrays consist of six identical floats, moving in six degrees of freedom, and six rotating power take-off systems, based on the design developed at Uppsala University. The goals of the work were to study and compare the performances of three different array layouts under several regular and irregular long-crested waves, and in addition, to determine whether the numerical predictions of the best performing array layouts were confirmed by experimental data. The simulations were executed with a frequency domain model restricted to heave, which is a computationally fast approach that was merged into a genetic algorithm optimization routine and used to find optimal array configurations. The results show that good agreement between experiments and simulations is achieved when the test conditions do not induce phenomena of parametric resonance, slack line and wave breaking. Specific non-linear dynamics or extensive sway motion are not captured by the used model, and in such cases the simulation predictions are not accurate, but can nevertheless be used to get an estimate of the power output.