In an oscillating water column (OWC)-type wave energy conversion system, the performance of the OWC chamber depends on the chamber shape, as well as the incident wave direction and pressure drop produced by the turbine. Although the previous studies on OWC chambers have focused on wave absorbing performance in ideal operating conditions, incident waves do not always arrive normally to the OWC chamber in real sea conditions, especially in fixed devices. The present study deals with experiments and numerical calculations to investigate the effects of wave direction on the performance of the OWC chamber. The experiments were carried out in a three-dimensional wave basin for five different wave directions, including the effect of turbine using the corresponding orifice. The wave elevation inside the chamber was measured at the center point under various incident wave conditions. The numerical study was conducted by using a numerical wave tank-based volume-of-fluid model to compare the results with experimental data and to reveal the detailed flows around the chamber.