Ocean Thermal Energy Conversion (OTEC) is a renewable energy source in which energy is produced by converting the heat stored in the sea or the ocean thermal energy into valuable work, based on the temperature difference between the warm surface seawater and the cold deep seawater. One of the OTEC system requirements is to have a seawater temperature difference at a minimum of 20 °C within a depth of 1000 m below sea level. Recognizing the importance of optimum sea water temperature, several studies have been conducted to optimize the OTEC system. However, none of these studies was attempted under a hybrid ocean thermal energy conversion (H-OTEC) setup. A H-OTEC system is a combination of closed-cycle and open-cycle OTEC system. The objective of this study is to evaluate the performance of the H-OTEC process system based on the impact of seawater temperature variation by simulating H-OTEC process system. Aspen HYSYS was used as a chemical process simulation platform for conducting this study. After the model was completed, verification test was conducted before the simulated data was recorded. The data for the pump work input and the turbine work output were acquired to determine the net power output and system efficiency. The net power output, Carnot efficiency, and thermal efficiency were recorded approximately 1.39 kW, 5.7%, and 1.45%. The data for net power output and the efficiencies of the system was recorded for every 1 °C of increment in surface seawater temperature. The results showed that the net power output increased slightly by 0.5kW, with efficiency difference for both Carnot cycle and actual cycle, recorded to be less than 3% and 0.1% respectively.