This paper describes a methodology to determine the optimal size of a Wells turbine to be used in an OWC device taking into account hydro-aerodynamic coupling, performance curves of the turbine and air pressure control by a relief valve. The proposed model, named turbine diameter optimization (TDO) model, considers the movement of the water surface inside the OWC chamber as a piston movement in response to the hydrodynamic forces from the incoming waves. The aerodynamic is based on the first law of thermodynamics applied to the air column of the chamber. The power-pressure curve of the turbine and the air pressure control by relief valve are implemented in the model to determine the turbine power output for several regular incident waves. The TDO model is initially calibrated by a numerical model based on Reynolds-Average-Navier-Stokes (RANS) equations for each wave component of an expected sea state distribution. Thereafter, the power output generated by turbines of several sizes is calculated with lower computational cost (few minutes) in comparison with RANS based models (thousands of hours) in a personal computer. This developed methodology is an important support to the process of turbine sizing for an OWC device for an expected sea state distribution.