In this work, innovative use of Salinity Gradient Power (SGP) as renewable energy source for indirect production of hydrogen is addressed. A lab-scale reverse electrodialysis (RED) unit, fed with different NaCl solutions mimicking highly concentrated brine (5 M), Reverse Osmosis retentate (1 M), seawater (0.5 M) and brackish water (0.1 M), was coupled to an alkaline polymer electrolyte (APE) water electrolysis cell. SGP-RED unit, equipped with 27 cell-pairs, reached at best an Open Circuit Voltage (OCV) of 3.7 V and maximum gross power density of 3.2 W m−2MP (membrane pair) when feeding the low concentration compartment (LCC) with 0.1 M NaCl and the High Concentration Compartment (HCC) with 5 M NaCl. The single-cell APE water electrolysis unit, operated at 1.8 V, attained a current density of 120 mA cm−2 under the following configuration: 10% w/w KOH electrolyte, highly conductive anion selective membrane composed of inert low-density polyethylene, finely milled anion selective particles and water-soluble poly (ethylene glycol-ran-propylene glycol), non-Platinum catalysts (NiCo2O4 and NiFe2O4) loading of 10 mg cm−2 and 15%w/w polymer binder at both cathode and anode, and operational temperature of 65 °C. The integrated system resulted in a maximum hydrogen production rate of 44 cm3 h−1 per cm2 of electrode surface area.