An analysis of reverse osmosis powered by ocean wave power is provided. A commercially available desalination system is connected via a DC/AC converter to a variable DC source and the input voltage is altered to emulate the response of a renewable energy system. Specifically, wave data from Kilifi in Kenya during 2015 is used. The wave resource variations provide variations in estimated power output from a wave energy converter, as well as in estimated freshwater production from a wave powered desalination system. Up to three wave energy converters for desalination are investigated for Kilifi. Also, a hybrid system including solar and wave power is proposed. The experiments show that reverse osmosis desalination systems can function at power levels below the rated values, but with lower freshwater flowrates. It is concluded that wave power, or wave power combined with PV systems, may be considered as power sources for desalination, with or without battery storage.