The coastal waters of Massachusetts, USA encompass tidal phenomena that generate flows of sufficient magnitude for commercially viable power extraction. We examine the tidal power resource of the Massachusetts coastal region with two high-resolution hydrodynamic tidal models: a regional model encompassing the coastal waters of southeastern New England and a local domain model of Cape Cod Canal. Both models have been subject to comprehensive skill assessment using available surface elevation and ADCP measurements. Based on the model results, we identify five high-energy sites (Cape Cod Canal, Muskeget Channel, Quicks Hole, Robinson Hole and Woods Hole) for evaluation of the maximum extractable tidal power. The power extraction at these sites is modeled using linear momentum actuator disk theory applied to a cross-channel array of turbines. Of the sites evaluated, Muskeget Channel has the greatest resource, with an estimated maximum extractable power of 24 MW. The estimated total power available from all five sites is 44 MW. These estimates agree within 21% with predictions from analytical approaches at all sites. Potential applications for the models include: providing developers with an initial assessment of the resource, guiding observation programs for further study of the resource, and facilitating optimization of turbine array design.