Various forms of energy conversion have been examined over the years and the energy of thermal gradients currently operating in some regions of the world has been studied. The Southern Brazilian Continental Shelf has high spatial and temporal temperature variability, indicating the need for a climatological analysis to identify the regions with the largest energy budgets. This region was shown to have a large energy budget through the analysis of sea surface temperature modelling data over 14 years. Based on the seasonality, the most suitable area for using an OTEC facility was identified. A numerical module forced with the monthly averaged modelling data was developed in order to estimates the thermal energy conversion from the ocean. The results show that there is a low sensitivity of the thermocline and thermal gradient associated with the change of seasons and oceanic features observed in this region. The theoretical maximum power produced can reach up to 121.9 MW and the average over the studied period was approximately 94.3 MW considering a punctual extraction spot. A simulated conversion site placed where there was greatest viability revealed that the average standard thermal gradient is 0.17 °C/m along the vertical column (545 m) from the sea.