Artificial neural networks (ANN) are extremely powerful analytical, parallel processing elements that can successfully approximate any complex non-linear process, and which form a key piece in Artificial Intelligence models. Its field of application, being very wide, is especially suitable for the field of prediction. In this article, its application for the prediction of the overtopping rate is presented, as part of a strategy for the sustainable optimization of coastal or harbor defense structures and their conversion into Waves Energy Converters (WEC). This would allow, among others benefits, reducing their initial high capital expenditure. For the construction of the predictive model, classical multivariate statistical techniques such as Principal Component Analysis (PCA), or unsupervised clustering methods like Self Organized Maps (SOM), are used, demonstrating that this close alliance is always methodologically beneficial. The specific application carried out, based on the data provided by the CLASH and EurOtop 2018 databases, involves the creation of a useful application to predict overtopping rates in both sloping breakwaters and seawalls, with good results both in terms of prediction error, such as correlation of the estimated variable.