An integrated wave-tidal current power turbine is affected by both wave and tidal current forces, and its energy efficiency is closely related to the velocity and direction of the two forces. To improve the probability of the horizontal axis turbine reaching maximum energy efficiency under real-time changing sea conditions, we performed the following investigations in this study. Based on the actual application scenario of Lianyungang port, a time series prediction model of tidal current (velocity and flow direction) and wave (mean wave direction, mean wave period, and significant wave height) data for the past year was established. The changes in waves and tidal currents within 24 h after the cutoff point of the existing data were predicted. The integrated wave-tidal current mechanism was studied, and the superposition of wave energy and tidal current energy was transformed into the equivalent velocity vector of wave-tidal current integration. The conversion coefficient between waves and equivalent flows was determined by a numerical wave flume simulation. According to the historical wave and tidal current data, the equivalent velocity range of the integrated action of waves and tidal currents in Lianyungang was determined. The influence of different blade motions on the energy harvesting efficiency of the turbine under the corresponding flow conditions was studied using the Computational Fluid Dynamics (CFD) method to determine the blade motion law of the turbine. The blade motion law of the prototype was verified in a sea trial experiment. The experimental results were basically consistent with the simulation results for the blade motion law designed according to the wave and tidal current prediction law. This design scheme can provide a reference for engineering design for the development and utilization of new marine energy.