We report a novel reverse electrodialysis (RED) chemical cell that integrates RED with acid/base neutralization. This RED neutralization process (REDn) approximately doubled the power density compared to a conventional RED stack (REDc), thanks to the additional salinity gradients established by H+ and OH– ions as a result of the neutralization reaction. Detailed analysis shows that the power performance, i.e., the open circuit voltage and power density, of the REDn cell was greatly limited by concentration polarization and uphill transport of ions. Addressing these issues could potentially lead to an order of magnitude improvement in power density as predicted by the Nernst equation. The current study provides a simple strategy for effectively extracting energy from the neutralization of waste acid and base solutions. Future studies shall further explore the treatment of acid mine drainage and landfill leachate with the RED chemical cell as well as its extension to a wider range of reactions.