This paper reports on the operation assessment of an electrical power generation system based upon cross-flow water turbines. The specific power take-off system has been tested in real-world conditions in a variety of scenarios and the experimental results have confirmed previous modeling assessments. Dynamical proprieties have been precisely identified and stable system operation over the entire operating range has been achieved. Steady-state characterization in terms of power coefficient has also been done, allowing the assessment of power generation system global efficiency and enabling the building of more precise models to be used in further simulations and assessments for power grid integration. Maximum power point tracking and other specific operation regimes such as angular position synchronization have also been validated.