Some countries are facing issues on freshwater and electricity production, which can be addressed with the use of renewable energy powered desalination systems. In the following study, a reverse osmosis desalination plant powered by marine current energy converters is suggested. The marine current energy converters are designed at Uppsala University in Sweden, specifically for utilizing low water speeds (1–2 m/s). Estimations on freshwater production for such a system, in South Africa, facing the Indian Ocean was presented and discussed. It is concluded that the desalination plant cannot by itself supply freshwater for a population all the time, due to periods of too low water speeds (<1 m/s), but for 75% of the time. By using ten marine current energy converters, each with a nominal power rating of 7.5 kW, combined with a reverse osmosis desalination plant and water storage capacity of 2800 m3, it is possible to cover the basic freshwater demand of 5000 people. More studies on the hydrokinetic resource of the Western Indian Ocean, system cost, technology development, environmental and social aspects are necessary for more accurate results.