The opportunity of using wave energy converter arrays in a hot spot area of the Mediterranean sea was investigated. For this purpose, numerical simulations of wave energy converters together with a simple cost-effective analysis were carried out. The selected study area is one of the most energetic inside the Sicilian channel (Italy). The numerical simulations were performed using the SNL-SWAN (“Sandia National Laboratories – Simulating WAves Nearshore”) spectral model with an unstructured mesh. The power absorbed from thirteen Wave Energy Converter (WEC) devices was computed. In particular, Pelamis, Wave Dragon, Oyster 2, Wavestar, B-HBA, B-OF, Bref-HB, Bref-SHB, F–2HB, F–3OF, F-HBA, F-OWC were investigated. Hydrodynamic stationary simulations of a WEC array parallel to the coastline were carried out in order to choose the best devices for a non-stationary simulation. The devices selected for this simulation are Pelamis, Wave Dragon, Oyster 2, F–2HB, and Bref-HB. The non-stationary simulation was forced with thirty-nine years wave parameters reanalysis from ERA5 by ECMWF (European Centre for Medium-range Weather Forecasts). This simulation has allowed to obtain the capacity factor (CF) and the dissipative effects in the period from 1979 to 2018. Moreover, a preliminary cost-to-benefit analysis was carried out for the best performance WEC array only. Costs, revenues, LCoE (Levelized Cost of Energy), and payback period were therefore computed by means of economic assumptions. The high energy concentration near the coast produces hydrodynamic effects which have as a consequence potential erosion phenomena. A shoreline change analysis of three beaches of the studied coast was carried out. Such an analysis was focused on shoreline retreatment during the last thirty years. On the basis of the presented results, there is a slight economic advantage in installing a Wave Dragon scaled array with the added value of potentially giving beneficial effects on coastal erosion. Nevertheless, from a strictly economic point of view, other renewable resources could give better results (e.g. wind energy). The adopted methodology gives encouraging results that confirm the opportunity to deploy WEC devices in the Sicilian channel together with devices exploiting other renewable resources.